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Principal Investigator

Gaorav P. Gupta, M.D., Ph.D. (gaorav_gupta@med.unc.edu)
Assistant Professor in the Division of Radiation Oncology at UNC-Chapel Hill School of Medicine

gaorav Our research interest is to understand the interplay between genome integrity pathways and breast cancer initiation, progression, and response to therapy. The DNA damage response (DDR) is an evolutionarily conserved network of DNA damage sensors, mediators, and effectors that is responsible for maintaining genomic integrity in the face of intrinsic (e.g. oxidized DNA, incorporated ribonucleotides, replication-associated single- and double-strand breaks) and extrinsic (e.g. ionizing radiation, alkylating agents, other clastogen exposures) DNA damage.  Germline aberrations in the DDR pathway are known to predispose to cancer (e.g. BRCA1-2, XPA-G, FANCA-P, etc.), but the significance of the DDR in sporadic tumorigenesis is only beginning to emerge.

Lab Manager

Christine Foster (christine_foster@med.unc.edu)

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Postdoctoral Researchers

Fagan-Solis, Katerina, Ph.D. (katerina_fagan-solis@med.unc.edu)

FB_IMG_1446426618119 Postdoctoral Research AssociateB.S. State University of New York at Albany
Ph.D., University of Massachusetts Amherst
Postdoctoral Fellow, North Carolina Central University
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Sunil Kumar, PhD (sunil02@med.unc.edu)

 sunil (2) Postdoctoral Research AssociateB.Sc. University of Delhi, New Delhi
M.Sc. DAVV, Indore
Ph.D., IIT Bombay, Mumbai
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Feng Wanjuan, Ph.D. (wanjuan@med.unc.edu)

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